The Era of Personalized Cancer Therapeutics
Isabel Levy & Seema Bachoo Glossary Adoptive T cell transfer, Allosteric site, Clonal expansion, CRISPR-Cas9, DNA, DNA sequencing, EGFR, ‘Gain-of-function’ mutation, Genome, Genomic Instability, GTPase, GDP, GTP, Kinase, ‘Loss-of-function’ mutation, MAPK signaling pathway, Mutation, Oncogene/Proto-oncogene, Personalized Cancer Medicine, PI3K pathway, RAS, TP53 gene, Tumor suppressor gene Background Cancer: a disease of the genome […]
The use of Stem Cells in Modern Medicine
Lovisa Lindquist Abbreviations CNS, central nervous system; ESC, embryonic stem cell; FDA, Food & drug administration; HLA, human leukocyte antigen; HSC, hematopoietic stem cell; ICM, inner cell mass; iPSC, induced pluripotent stem cell; IVF, in vitro fertilization; MS, multiple sclerosis; MSC, mesenchymal stem cells; SC, stem cell Glossary Adipose tissue, Amniotic sac, Antigen, Autoimmune […]
Genomics: The Advent of Preventative Medicine?
Olivia Crossley Glossary Amniocentesis, Cell, Amyotrophic lateral sclerosis, Chorionic villus sampling, Chromosome, COVID-19, CRISPR-Cas9, Cystic fibrosis, DNA, Duchenne Muscular Dystrophy, Etiology, Familial Hypercholesterolemia, Gene, Genetic Counselling, Genetic Testing, Hemophilia, Leopard syndrome, Mucopolysaccharidosis type I, Noncoding DNA, Parkinson’s disease, Pharmacogenomics, Phenylketonuria, Precision Medicine, Prenatal testing, Severe Combined Immunodeficiency Disorder, Spinal Muscular Atrophy What is […]
COVID-19: How will testing and vaccines have to adapt to new variants?
Joana Vidigueira Glossary Antibody, Antigen, Antigen-presenting Cell, B cell, Booster, Clinical Trial, COVID-19, Dendritic Cell, Deoxyribonucleic Acid, Epidemiology, Helper T-cell, Host Cell, Immunity, Immune Response, Killer T-cell, Lymph Node, Macrophage, Mutation, Ribonucleic acid, RT-PCR, SARS-CoV-2, Vaccine, Variant, Virus Abbreviations SARS: Severe Acute Respiratory Syndrome, CoV: coronavirus, MERS: Middle Eastern Respiratory Syndrome, DNA: deoxyribonucleic acid, […]
Pharmacogenomics: The future of medicine?
Celeste Cohen Picture credit: National Human Genome Research Institute Note: All terms shown in bold are defined in the glossary at the end of the article. Defining Pharmacogenomics From chemotherapy to HIV drugs, the past century has seen rapid advances in medical innovation, which have given rise to a wide range […]
How immunotherapy can improve colorectal cancer prognosis
Aaron Logsdon Abbreviations CAR, chimeric antigen receptor; CAR-T, chimeric antigen receptor T lymphocyte therapy; CRC, colorectal cancer; DCR, disease control rate; dMMR, mismatch repair-deficient; FDA, US Food and Drug Administration; ICI, immune checkpoint inhibition; MMR, mismatch repair genes; MSI-H, high microsatellite instability; MSS, microsatellite stable; OR, objective response; pMMR, mismatch repair proficient; Treg, T […]
What is meant by the terms Personalized and Precision Medicine?
Lovisa Lindquist Glossary Cell Cycle, Chromosome, Cystic Fibrosis, CFTR gene, Deletion, DNA, Epigenetics, Frameshift Mutation, Gene, Gene Therapy, Genetic Testing, Genotype, Inversion, mRNA, Mutation, Personalized Medicine, Phenotype, Precision Medicine, Protein, Translocation, Tumour Heterogeneity, Tumor Suppressor Gene Currently, the majority of healthcare systems around the world employ a ‘one-size-fits-all’ approach when treating patients that have […]
Advanced Therapies Congress & Expo 2021
On the 5th of October, 2021, PMM team members Celeste Cohen, Shannon Hylton, and Aaron Logsdon attended the Advanced Therapies Congress held at the London ExCeL. The Advanced Therapies Congress explored, defined, and attempted to tackle the main challenges currently being faced when it comes to the development of patient access to advanced therapy medicinal products […]
Huntington’s disease: prevention and current innovations in treatment
Huntington’s disease: prevention and current innovations in treatment Jenny Chatzigerou Glossary Allele, Antibody, Autosomal, DNA, Gene, MicroRNA, mRNA, Neurodegenerative disorder, Neuron, Neuroleptic, Neurotransmitter, Nucleotide, Polymorphism, RNA Huntington’s disease (HD) is a genetic neurodegenerative disorder that was first described in 1872 by the physician George Huntington,1 in his seminal paper ‘On Chorea’. Huntington described the condition […]