Potential Uses of Stem Cells Derived from Umbilical Cord Blood

Maariya Rachid Daud   Glossary Amino Acid, Anemia, Arteries, Biobanks, Blood, Bone marrow, Cancer, Carcinogenesis, Carbon Dioxide, Cardiovascular, Conditioning Regimen, Cord blood,  Embryo, Endothelial Cell, Epithelial Cells, Fetus, Glucose, Graft Versus Tumor, Graft Versus Host Disease, Hematopoietic Stem Cells, Homeostasis, Immunophenotyping, Leukemia, Lumen, Mesenchymal, Metabolic disorders, Oxygen, Peripheral blood, Pregnancy, Receptors, Red blood cells, Sickle […]

How clinical trials work and the critical role that they play in drug development

Mathumai Govindarajan Abbreviations Adverse Drug Reaction (ADR); Clinical Trials Authorization (CTA); FDA Adverse Event Reporting System (FAERS); Food and Drug Administration (FDA); Medicines and Healthcare Products Regulatory Agency (MHRA); New Drug Application (NDA); Non-small Cell Lung Cancer (NSCLC); Overall Survival (OS); Population, Intervention, Comparator, Outcomes (PICO); Progression-free Survival (PFS); Randomized Clinical Trials (RCT); Therapeutics Goods […]

Personalized & precision medicine approaches for the treatment of cardiovascular disease

Isabela Garcia Pleijlar   Abbreviations CAD, Coronary Artery Disease; CHD, Congenital Heart Disease; CVD, Cardiovascular Disease; DNA, Deoxyribonucleic acid; ESCs, Embryonic Stem Cells; FDA, Food and Drug Administration; FRESH, Freeform Reversible Embedding of Suspended Hydrogels; hERG, the human ether-a-go-go related gene; hESC-CM, human Embryonic Stem Cell-derived Cardiomyocytes; HGF, Hepatocyte Growth Factor; hiPSC-CMs, human induced Pluripotent […]

Stem cell therapy as a potential treatment for breast cancer

Xuanqi Song Glossary Aromatase inhibitor, Astrocyte, Blastocyst, Chemotherapy, Ectoderm, Endoderm, Hematopoetic, Immunotherapy, in vitro, Lymphoma, Mesenchymal, Mesoderm, Molecular marker, Mutation, Pluripotent, Pluripotent, Quiescence, Somatic cell, Stem cell therapy Abbreviations Ais, Aromatase inhibitors; ASC, adult stem cell; CSC, cancer stem cell; ESC, embryonic stem cell; HER2, Human epidermal growth factor receptor 2; HR+, hormone receptor positive; […]

Prostate cancer research: Latest advances

Tala Elremmash   Glossary: Brachytherapy, BRCA genes, Digital Rectal Examination (DRE), External Beam Radiation Therapy (EBRT), ExoDx Prostate (EPI), 68Ga-PSMA-11, Gleason Score, High Intensity Focused Ultrasound (HIFU), Intensity Modulated Radiation Therapy (IMRT), 4Kscore Test, Multiparametric Magnetic Resonance Imaging (mpMRI), PCA3, Prostatic Intraepithelial Neoplasia (PIN), Prostate-Specific Antigen (PSA), Prostate-specific Membrane Antigen Positron Emission Tomography (PSMA-PET), Stereotactic […]

Glioblastoma: Current Therapies and Recent Therapeutic Advances

Eleanor Doherty   Glossary Antibody, Antidepressant, Antigen, Apoptosis, Astrocyte, CAR-T Cell Therapy, Atypia, Clinical Trial, CNS, Dendritic Cell Vaccine, Epidermal Growth Factor, Ex-Vivo, Glioblastoma Multiforme, Glioma, Immunotherapy, Metastasis, Mitotic Activity, Monoclonal Antibody, Necrosis, Neuron, Neurotransmitter, Oncology, Oncolytic Virotherapy, Prognosis, Radiotherapy, Stem Cell, Surgical Resection, Tumor, Vaccine Therapy, Vascular Endothelial Growth Factor   Abbreviations BBB, blood-brain […]

The Era of Personalized Cancer Therapeutics

  Isabel Levy & Seema Bachoo Glossary Adoptive T cell transfer, Allosteric site, Clonal expansion, CRISPR-Cas9, DNA, DNA sequencing, EGFR, ‘Gain-of-function’ mutation, Genome, Genomic Instability, GTPase, GDP, GTP, Kinase, ‘Loss-of-function’ mutation, MAPK signaling pathway, Mutation, Oncogene/Proto-oncogene,  Personalized Cancer Medicine, PI3K pathway, RAS, TP53 gene, Tumor suppressor gene   Background Cancer: a disease of the genome […]

Human African trypanosomiasis (HAT): past to present and beyond

Aaron Logsdon   Abbreviations BBB, Blood brain barrier; DDT, dichlorodiphenyltrichloroethane; DRC, the Democratic Republic of the Congo; HAT, Human African Trypanosomiasis; NECT, nifurtimox-eflornithine combination therapy; NTD, neglected tropical disease; ODC, ornithine decarboxylase; VSG, variant surface glycoprotein   Glossary antigen, antigenic variation, arsenic, asymptomatic, clinical trial, dementia, drug, drug resistance, energy metabolism, endemic, epidemic, fever, host, […]

The use of Stem Cells in Modern Medicine

Lovisa Lindquist   Abbreviations CNS, central nervous system; ESC, embryonic stem cell; FDA, Food & drug administration; HLA, human leukocyte antigen; HSC, hematopoietic stem cell; ICM, inner cell mass; iPSC, induced pluripotent stem cell; IVF, in vitro fertilization; MS, multiple sclerosis; MSC, mesenchymal stem cells; SC, stem cell Glossary Adipose tissue, Amniotic sac, Antigen, Autoimmune […]

What is Digital Health and how is it revolutionizing healthcare?

Olivia Crossley   Keywords Arrhythmia, Artificial intelligence, Blood Pressure, Consultant, Digital health, Electrodes, EEG, ECG, FDA, Machine Learning, Side effects, Telemedicine, Ultrasound, UK’s General Data Protection Regulation, Wearable technologies Digital technologies are electronic devices that analyze and store different kinds of information. These technologies have revolutionized how we communicate, learn, and shop. Now, digital devices […]